CAR models: next-generation CAR modifications for enhanced T-cell function
نویسندگان
چکیده
منابع مشابه
CAR models: next-generation CAR modifications for enhanced T-cell function
T cells genetically targeted with a chimeric antigen receptor (CAR) to B-cell malignancies have demonstrated tremendous clinical outcomes. With the proof in principle for CAR T cells as a therapy for B-cell malignancies being established, current and future research is being focused on adapting CAR technology to other cancers, as well as enhancing its efficacy and/or safety. The modular nature ...
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Chimeric antigen receptor (CAR) T-cell therapy is entering a new era, transitioning from an experimental approach being tested in a handful of centers to a more mainstream and broadly investigated therapeutic platform with significant efforts directed towards commercial translation. CARs are synthetic receptors engineered and transduced into T cells to redirect T-cell cytotoxicity by recognitio...
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ژورنال
عنوان ژورنال: Molecular Therapy - Oncolytics
سال: 2016
ISSN: 2372-7705
DOI: 10.1038/mto.2016.14